Levels of Myostatin, Adiponectin and Lipid Profile in Hyperlipidemia Patients

Authors

  • Safa Mansor Rashid University of Samarra, College of Applied Sciences
  • Raghad Hazem Alabbasy Samarra University College of Applied Sciences https://orcid.org/0000-1245-1487-5256
  • Aseel Mokdad Hatam Abdul Wahed University of Samarra, College of Applied Sciences, Samara, Iraq.

DOI:

https://doi.org/10.32441/ijms.6.3.3

Keywords:

TC, TG, HDL, Hyperlipidemia, Myostatin, Adiponectin

Abstract

Background: Excess fat is one of the biggest risk factors for the development of heart disease and one of the top five leading causes of death. The researchers expect from their study that deaths due to cardiovascular diseases will increase from (17.3) million cases in 2017 to (23.6) million deaths by 2030.

Aim: Determination of the concentration of lipid profile variables (TC, TG, HDL-C, LDL-C, VLDL-C). Estimating the concentration of some hormones such as myostatin and adiponectin in the serum of study samples in males and females with hyperlipidemia at different ages.

Materials and methods: The study included collecting (90) samples and dividing them into two groups (20-60).Blood samples were collected from the vein (10ml) using medical syringes, and the blood was placed in plastic tubes, where the samples were left for (15-20) minutes at a temperature of 37 °C in a water bath until the blood coagulated, and then the samples were separated in a centrifuge.

Results: the results showed a significant increase in each of TC, TG, LDL and VLDL, and a significant decrease in Myostatin and HDL, while the results showed no significant difference in Adiponectin. In females compared to healthy subjects the results showed a significant increase in TC, TG, LDL, and VLDL, and the results showed a significant decrease in HDL, while the results showed that there was no significant difference in both Adiponectin and Myostatin.

Conclusions: We conclude from our current study that hyperlipidemia is associated with an imbalance in the level of muscular lipid movements and is therefore considered a risk factor for the occurrence of cardiovascular diseases and requires follow-up and a healthy diet with treatment.

References

Piché ME, Tardif I, Auclair A, Poirier P. Effects of bariatric surgery on lipid - lipoprotein profile. Metabolism , 2021;115:154441 .

Wolska A, Dunbar RL, Freeman LA, Ueda M, Amar MJ, Sviridov DO, et al. Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism. Atherosclerosis,2017;267:49-60.

Okosun RE, Adu ME. Effect of oral vitamin E on serum lipid profile of apparently healthy Nigerians in Benin City. Tropical Journal of Pharmaceutical Research,2015; 14(6):1071-1074.

Marshall WJ, Bangert SK. Clinical chemistry 6th ed, Edinburgh mosby,2008.

Lee SJ. Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction . J Clin Invest, 2021;131(9): e148372 .

Nguyen TMD. Adiponectin : role in physiology and pathophysiology. Int J Prevent Medicine , 2020;11:136.

Berrougui H, Momo CN, Khalil A. Health benefits of high density lipoproteins in preventing cardiovascular diseases. Journal of clinical lipidology,2012; 6(6):524-533.

Stadler JT, Marsche G. Obesity-related changes in high-density lipoprotein metabolism and function. International journal of molecular sciences, 2020; 21(23): 8985.‏

Khatana C, Saini NK, Chakrabarti S, Saini V, Sharma A, et al. Mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis. Oxidative Medicine and Cellular Longevity, 2020.‏

Han DS, Chu-Su Y, Chiang CK, Tseng FY, Tseng PH, Chen CL, et al. Serum myostatin is reduced in individuals with metabolic syndrome. PLoS One,2014; 9(9), e108230.‏

Packard CJ, Boren J, Taskinen MR.Causes and consequences of hypertriglyceridemia. Frontiers in endocrinology, 2020;11:252

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Published

2023-08-01

How to Cite

Rashid, S. M. ., Alabbasy, R. H. ., & Abdul Wahed, A. M. H. . (2023). Levels of Myostatin, Adiponectin and Lipid Profile in Hyperlipidemia Patients. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 6(3), 27–30. https://doi.org/10.32441/ijms.6.3.3