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Sarah Basil Fawzi Fawzi sarah.mchs24@ced.nahrainuniv.iq
Khalid Younis Zainulabdeen khalid.waleed21@nahrainuniv.edu.iq
Emad Abdul-Hussain Yousif emad_yousif@nahrainuniv.edu.iq
Husnun Amalia Enus Yunus husnun_a@trisakti.ac.id
Nany Hairunisa Muhaini Umar nanyhairunisa@trisakti.ac.id


Abstract

Benzimidazole and its structural analogues have garnered significant attention across diverse disciplines, including the fields of medicine and agriculture, owing to their remarkable versatility and immense potential. This review article aims to elucidate the multifaceted importance of benzimidazole-based compounds and their derivatives within these spheres. The paper starts by establishing the pivotal role of benzimidazoles in human health and pharmaceutical applications. A comprehensive examination of their therapeutic utility in treating and managing various diseases is undertaken, underscoring the compounds' potent biological activities and clinical relevance. Furthermore, the review focused on the applications of benzimidazole-based compounds as powerful fungicides and pesticides within the agricultural sector. The discussion covers the mechanistic underpinnings of their efficacy, formulation challenges, and regulatory considerations surrounding their deployment in the agrochemical industry. This paper aims to demonstrate the extensive applications of these heterocyclic moieties and their derivatives in medicine and farming. The in-depth analysis presented herein is intended to facilitate a deeper understanding of the versatility and importance of benzimidazole compounds, thus enriching future research and development endeavors within these critical domains.

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How to Cite
Fawzi, S. B. F., Zainulabdeen, K. Y., Yousif, E. A.-H., Yunus, H. A. . E., & Umar, N. H. M. (2024). Benzimidazole and Its Derivatives: Exploring Their Crucial Role in Medicine and Agriculture: A Short Review . Al-Kitab Journal for Pure Sciences, 8(02), 125–137. https://doi.org/10.32441/kjps.08.02.p11
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References

Jiyaul H, Amit A. Study on Benzimidazole: A Comprehensive Review. Int J Multidiscip Res. 2023. doi: 10.36948/ijfmr.2023.v05i02.1931.

Sharma S, Dangi N, Mittal N, Kalra N. A Critical Analysis of the Modern Synthetic Procedures Used to Produce Benzimidazole Candidates. Curr Organocatal. 2023. doi: 10.2174/2213337210666230329103657.

Rudolph A, Champa KA, Vishnumurthy, Yadav D, Bodke HS, Bhojya Naik, et al. Synthesis, characterization, and biological investigations of potentially bioactive heterocyclic compounds containing benzimidazole nucleus. Results Chem. 2023. doi: 10.1016/j.rechem.2023.101018.

Choudhary A, Viradiya RH, Ghoghari RN, Chikhalia KH. Recent Scenario for the Synthesis of Benzimidazole Moiety (2020–2022). ChemSelect. 2023. doi: 10.1002/slct.202204910.

Sharma S, Gupta MC, Gupta M, Sahu JK. Significance of Benzimidazole analogues for the creation of novel molecules in drug discovery. Curr Chem Lett. 2023. doi: 10.5267/j.ccl.2022.9.008.

Benzimidazole [Internet]. Available from: https://en.wikipedia.org/wiki/Benzimidazole.

Rudolph A, Champa KA, Vishnumurthy, Yadav D, Bodke HS, Bhojya Naik, et al. Synthesis, characterization, and biological investigations of potentially bioactive heterocyclic compounds containing benzimidazole nucleus. Results Chem. 2023. doi: 10.1016/j.rechem.2023.101018.

Aralihalli S, Sudileti M, Aithal SJ. The medicinal panorama of benzimidazoles and their scaffolds as anticancer and antithrombotic agents: A review. Arch Pharm. 2023. doi: 10.1002/ardp.202300206.

Chevallier F, Mongin F. Functionalization of Diazines and Benzo Derivatives Through Deprotonated Intermediates. ChemInform. 2008. doi: 10.1002/CHIN.200824242.

Jeon BH. A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy. Molecules. 2023. doi: 10.3390/molecules28145490.

Sahu JK, Sharma S, Gupta M, Gupta MC. Impact of Benzimidazole containing scaffolds as Anticancer Agents through diverse modes of action. Curr Bioact Compd. 2023. doi: 10.2174/1573407219666230406082148.

Saini A, Kumar G, Singh GD. A review of Benzimidazole derivatives' potential activities. Int J Pharm Clin Res. 2023. doi: 10.33545/26647591.2023.v5.i1a.51.

Salahuddin, Shabana K, Mazumder A, Kumar R, Datt V, Tyagi S, et al. Review on the discovery of new Benzimidazole derivatives as Anticancer Agents: Synthesis and Structure-Activity Relationship (2010-2022). Lett Drug Des Discov. 2022. doi: 10.2174/1570180820666221017155955.

Singh HP, Kumar R, Tiwari P, Singh A. Recent advances in Synthetic Strategies of Benzimidazole and Its Analogs: A Review. Curr Org Chem. 2022. doi: 10.2174/1385272827666221216113723.

Aminov RI. A brief history of the antibiotic era: lessons learned and challenges for the future. Front Microbiol. 2010;1:134.

Kale PA, Kaduskar SD. A REVIEW ON SYNTHESIS AND CHARACTERISATION OF BENZIMIDAZOLE. 2023.

Rana NA, Zahraa L, Razzaq WI, Yahya I. Synthesis, Characterization and Studying Biological Activity of Heterocyclic Compounds. Int J Drug Deliv Technol. 2023. doi: 10.25258/ijddt.13.1.31.

Thakur D. A Review on the Medicinal Significance of Heterocyclic Compounds. Int J Sci Technol Eng. 2023. doi: 10.22214/ijraset.2023.54569.

Gulati S, Singh R, Sangwan S. A review on green synthesis and biological activities of medicinally important nitrogen and oxygen containing heterocycles. Curr Org Chem. 2022. doi: 10.2174/1385272827666221227114713.

Sarria JJH. Synthesis of Bioactive Heterocycles Exploiting Modern Continuous Flow Chemistry. 2022. doi: 10.1002/9781119757153.ch12.

Chérif SE, Ghosh A, Chelli S, Dixon IM, Kraiem J, Lakhdar S. Merging Grubbs second-generation catalyst with photocatalysis enables Z-selective metathesis of olefins: scope, limitations, and mechanism. Chem Sci. 2022. doi: 10.1039/d2sc03961c.

Vasantha TS, Mani S, Pasha TY, Ramesh B. A comprehensive review on 2-substituted benzimidazole derivatives and its biological importance. 2023.

Hak J, Agrawal A. Study on Benzimidazole: A Comprehensive Review. Int J Multidiscip Res. 2023. doi: 10.36948/ijfmr.2023.v05i02.1931.

Pullagura MKP, Kanvinde A, Raja S. Potent biological agent benzimidazole-a review. Int J Pharm Pharm Sci. 2016;8:22-33.

Sahu JK, Sharma S, Gupta M, Gupta MC. Impact of Benzimidazole containing scaffolds as Anticancer Agents through diverse modes of action. Curr Bioact Compd. 2023. doi: 10.2174/1573407219666230406082148.

Abdullah AM, Dadoosh SA, Thani MZ, Fahad AS. Using Metal Oxide Nanoparticles as Catalyst in Benzimidazoles Synthesis. Earthline J Chem Sci. 2023;9(1):63-76.

Venugopal S, Kaur B, Verma AK, Wadhwa P, Sahu SK. A Review On Modern Approaches To Benzimidazole Synthesis. Curr Org Synth. 2022. doi: 10.2174/1570179420666221010091157.

Fujihara H, Fujii K, Fuchi S, Tanaka R, Akimoto K. Benzimidazole compound or salt thereof, agricultural and horticultural insecticidal and acaricidal agent comprising said compound, and method for using said insecticidal and acaricidal agent. 2021.

Al Nasr I, Koko WS, Khan T, Schobert R, Biersack B. Antiparasitic Activity of Fluorophenyl-Substituted Pyrimido[1,2-a]benzimidazoles. Adv Cardiovasc Dis. 2023. doi: 10.3390/biomedicines11010219.

Chai JY, Jung BK, Hong SJ. Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update. Korean J Parasitol. 2021. doi: 10.3347/KJP.2021.59.3.189.

Conaldnbww. Benzimidazole Zinc Complexes and Their Anticancer Activities. 2023. doi: 10.58830/ozgur.pub132.c673.

Kotovskaya SK, Baskakova ZM, Charushin VN, Chupakhin ON, Belanov EF, Bormotov NI, Serova OA. Synthesis and antiviral activity of fluorinated pyrido[1,2-a]benzimidazoles. Pharm Chem J. 2005;39:574-8.

Chiebuka P. Impacts of Environmental Challenges on Medicinal Plants and the Possibilities for Increased Sustainable Agriculture. Covenant J Entrepreneurship. 2020;4(1).

Heneberg P, Svoboda J, Pech P. Benzimidazole fungicides are detrimental to common farmland ants. Biol Conserv. 2018;221:114-7.

Agarwal SK. Pesticide Pollution. Vol. 3. APH Publishing; 2009.

Abdel Gawad M, Eissa M, El-Gindi AE, Smart G. Development of plant-parasitic nematode populations on forage crops under field conditions. Egypt J Agronematol. 2017;16(2):51-62.

Karunarathna SC, Ashwath N, Jeewon R. The Potential of Fungi for Enhancing Crops and Forestry Systems. Front Microbiol. 2021;12:813051.

Jampílek J, Kráľová K, Campos EV, Fraceto LF. Bio-based nanoemulsion formulations applicable in agriculture, medicine, and food industry. In: Nanobiotechnology in bioformulations. 2019. p. 33-84.

Dhevagi P, Ramya A, Priyatharshini S, Geetha Thanuja K, Ambreetha S, Nivetha A. Industrially important fungal enzymes: productions and applications. Recent Trends Mycol Res: Environ Ind Perspect. 2021;2:263-309.

Aftab NF, Ahmad KS, Gul MM. Sorptive and degradative assessments of environmentally pestilential Benzimidazole fungicide Fuberidazole in pedosphere. Int J Environ Anal Chem. 2023;103(17):6097-114.

Saïf EC, Ghosh A, Chelli S, Dixon IM, Kraiem J, Lakhdar S. Merging Grubbs second-generation catalyst with photocatalysis enables Z-selective metathesis of olefins: scope, limitations, and mechanism. Chem Sci. 2022. doi: 10.1039/d2sc03961c.

He G, Deng S, Nooh MN, Ahmad BS, Yu R, Abram J, et al. Proton Pump Inhibitors and Cancer Risk. Am J Clin Oncol. 2022. doi: 10.1097/coc.0000000000000949.

Ravindra BN, Sunny DS, Jain D. Study on Drug Utilization and Evaluation of Proton Pump Inhibitors in Surgery Unit of Tertiary Care Teaching Hospital. Int J Pharm Sci Rev Res. 2022. doi: 10.47583/ijpsrr.2022.v76i01.011.

Singh HP, Kumar R, Tiwari P, Singh A. Recent advances in Synthetic Strategies of Benzimidazole and Its Analogs: A Review. Curr Org Chem. 2022. doi: 10.2174/1385272827666221216113723.

He G, Deng S, Nooh MN, Ahmad BS, Yu R, Abram J, et al. Proton Pump Inhibitors and Cancer Risk. Am J Clin Oncol. 2022. doi: 10.1097/coc.0000000000000949.

Patil GD, Nikam AR, Karanke NB, Shaikh AZ. A Short Review On Benzimidazole and Their Derivatives. 2020. doi: 10.46624/AJPHR.2020.V8.I3.002.

Ahmad N, Azad MI, Khan AR, Azad I. Benzimidazole as a promising antiviral heterocyclic scaffold: a review. 2021. doi: 10.46939/J.SCI.ARTS-21.1-B05.

Brishty SR, Hossain MJ, Khandaker MU, Faruque MRI, Osman H, Rahman SMA. A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives. Front Pharmacol. 2021;12:762807. doi: 10.3389/fphar.2021.762807.

Bridoux M, Simon N, Turpin A. Proton Pump Inhibitors and Cancer: Current State of Play. Front Pharmacol. 2022. doi: 10.3389/fphar.2022.798272.

Soong JTY. Proton pump inhibitors: When is it too much of a good thing? Ann Acad Med Singapore. 2022. doi: 10.47102/annals-acadmedsg.20226.

Imparato RR, Toma TS. Proton pump inhibitor deprescription: A rapid review. Braz J Pharm Sci. 2022. doi: 10.1590/s2175-97902022e19989.

Orel R, Benninga MA, Broekaert I, Gottrand F, Papadopoulou A, Ribes-Koninckx C, et al. Drugs in Focus: Proton Pump Inhibitors. J Pediatr Gastroenterol Nutr. 2021. doi: 10.1097/MPG.0000000000003063.

Singh L, Kanwar K, Singh AP. Proton pump inhibitors: An incisive review. Int J Parallel Program. 2021. doi: 10.18231/J.IJPP.2021.019.

Perry IE, Sonu I, Scarpignato C, Akiyama J, Hongo M, Vega KJ. Potential proton pump inhibitor–related adverse effects. Ann N Y Acad Sci. 2020. doi: 10.1111/NYAS.14428.

Saini S, Majee C, Chakraborthy GS, Salahuddin. Novel Synthesis of Omeprazole and Pharmaceutical Impurities of Proton pump inhibitors: A Review. Int J PharmTech Res. 2019. doi: 10.20902/IJPTR.2019.120307.

Cartee NMP, Wang MM. Binding of omeprazole to protein targets identified by monoclonal antibodies. PLoS One. 2020. doi: 10.1371/JOURNAL.PONE.0239464.

Bruni AT, Ferreira MMC. Theoretical study of omeprazole behavior: Racemization barrier and decomposition reaction. Int J Quantum Chem. 2008. doi: 10.1002/QUA.21597.

Malik S, Das S, Jain B. First-row transition metal complexes of omeprazole as anti-ulcerative drugs. Indones J Chem. 2010;10(3):382-9.

Claramunt RM, López C, Alkorta I, Elguero J, Yang R, Schulman S. The tautomerism of Omeprazole in solution: a 1H and 13C NMR study. Magn Reson Chem. 2004. doi: 10.1002/MRC.1409.

Claramunt RM, López C, Elguero J. The structure of Omeprazole in the solid state: a 13C and 15N NMR/CPMAS study. Arkivoc. 2005. doi: 10.3998/ARK.5550190.0007.502.

Bruni AT, Ferreira MMC. Theoretical study of omeprazole behavior: Racemization barrier and decomposition reaction. Int J Quantum Chem. 2008. doi: 10.1002/QUA.21597.

Murray IA, Perdew GH. Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon Receptor Activation. J Pharmacol Exp Ther. 2008. doi: 10.1124/JPET.107.13224.

Singh SP, Siddiqui MJ, Mukarram D, Kulkami G, Purohit M. Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole. 1999.

Vora JJ, Trivedi KP, Kshatriya RS. Synthesis and Spectral Studies of 2-mercapto-5-methoxy-1H-benzimidazole: An Imperative Medicinal Intermediate. 2012.

Nikiforova OV, Chistyakov VV, Shikh EV, Arzamastsev AP. Pharmacokinetics and bioaccessibility of gastrozole. Pharm Chem J. 1999. doi: 10.1007/BF02509933.