Levels Estimation of Iron, Zinc and Copper in the Serum of Children Infected with Giardiasis
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Abstract
Giardiasis is an infection in the small intestine, it’s caused by a microscopic parasite called Giardia lamblia. In this study, we examined stool samples for 75 children, 1–12 years old during the period from August to November 2023 from children who attended a pediatric hospital in Kirkuk city, and we estimated the levels of iron, zinc, and copper in these children. A stool examination was done for all samples to detect cysts or trophozoites of Giardia lamblia. Also, we measured the levels of iron, zinc, and copper by atomic absorption spectrophotometer. The highest rate of parasite infection (66.7%) was recorded in the age group (4–6 )years old. Serum iron and copper levels considerably decreased (P<0.05) in comparison to the control group. It was noted that most of the infected children suffer from abdominal pain with intermittent diarrhea.
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Coles CL, Levy A, Dagan R, Deckelbaum RJ, Fraser D. Risk factors for the initial symptomatic giardia infection in a cohort of young Arab-Bedouin children. Ann Trop Paediatr. 2009;29:291–300.
Brooks GF, Carroll KC, Butel JS, Morse SA, Mietzner TA. Jawetz, Melnick, and Adelberg's Medical Microbiology. 26th ed. McGrew-Hill Companies; 2013. p. 719-720.
Farthing MJ. New perspectives in giardiasis. J Med Microbiol. 1992;37:1–2.
Parija SC. Intestinal, oral and genital flagellates. In: Textbook of Medical Parasitology (Protozoology and Helminthology). 2nd ed. All India Publisher and Distributor, Chennai; 2004. p. 62–70.
Karakas Z, Demirel N, Tarakcioglu M, Mete N. Serum zinc and copper levels in southeastern Turkish children with giardiasis or amebiasis. Biol Trace Elem Res. 2001;84:11–18.
Ertan P, Yereli K, Kurt O, Balcioglu IC, Onag A. Serological levels of zinc, copper and iron elements among Giardia lamblia infected children in Turkey. Pediatr Int. 2002;44:286–288.
Garcia LS. Laboratory methods for diagnosis of parasitic infections. In: Baron EJ, Finegold SM, editors. Bailey and Scott's Diagnostic Microbiology. 8th ed. St. Louis: C. V. Mosby; 1990. p. 776–861.
Khana LTY, Fouad PS, Haddad DN. Study on prevalence of Giardia lamblia among patients attending Pediatric Hospital in Kirkuk City and its effect on some hematological parameters. Hospital. 2017;7(4):71-73.
Alsadoon Z, Whaeeb ST, Abduwahed TK. The effect study of the gender and age on prevalence Giardiasis in Baghdad Governorate-Iraq. Mater Today Proc. 2021;24:10-2.
Al Saeed AT, Issa SH. Frequency of Giardia lamblia among children in Dohuk, northern Iraq. EMHJ-Eastern Mediterranean Health Journal. 2006;12(5):555-561.
Mohammed BA, Rasheed ZK, Jihad LJ, Abass KS. Frequency of Giardia lamblia among Iraqi children in Kirkuk governorate. Systematic Reviews in Pharmacy. 2020;11(12):1909-1911.
Hawrelak J. Giardiasis: pathophysiology and management. Altern Med Rev. 2003;8:129–142.
Saldiva SR, Silveira AS, Philippi ST, Torres DM, Mangini AC, Dias RM, et al. Ascaris-Trichuris association and malnutrition in Brazilian children. Paediatr Perinat Epidemiol. 1999;13:89–98.
Ulukanligil M, Seyrek A. Demographic and socio-economic factors affecting the physical development, haemoglobin and parasitic infection status of school children in Sanliurfa province, Turkey. Pub Health. 2004;118:151-158.
Squitti R, Lupoi D, Pasqualetti P, Dal Forno G, Vernieri F, Chiovenda P, et al. Elevation of serum copper levels in Alzheimer's disease. Neurology. 2002;59:1153–1161.
Culha G, Sangun MK. Serum levels of zinc, copper, iron, cobalt, magnesium, and selenium elements in children diagnosed with Giardia intestinalis and Enterobiosis vermicularis in Hatay, Turkey. Biol Trace Elem Res. 2007;118:21–26.
Delibas N, Aydemir M, Ayata A, Demirci M, Tarhan V. Serum Fe, Zn, Cu and SOD activity levels in children with giardiasis. Acta Parasitol Turcica. 1996;20:25–9.
Demirci M, Delibas N, Altuntas I, Oktem F, Yonden Z. Serum iron, zinc and copper levels and lipid peroxidation in children with chronic giardiasis. J Health Popul Nutr. 2003;21:72–75.
Roxstrom-Lindquist K, Palm D, Reiner D, Ringqvist E, Svard SG. Giardia immunity—an update. Trends Parasitol. 2006;22:26–31.
Gunduz Z, Yavuz I, Koparal M, Kumandas S, Saraymen R. Serum and cerebrospinal fluid zinc levels in children with febrile convulsions. Acta Paediatr Jpn. 1996;38:237–41.