Nuha H. Kh. Alterations in Serum Lactate Dehydrogenase and Creatine Kinase Levels in Relation to Physical Activity Intensity Exercise Intensity–Induced Changes in Serum LDH and CK Levels
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Abstract
The objective of this study was to investigate how muscle-related enzymes, i.e., creatine kinase (CK) and lactate dehydrogenase (LDH), depend on various degrees of physical exercise intensity in apparently healthy individuals. The study participants, 180 in number, between 20 and 50 years old, were selected from Kirkuk city and divided into three groups according to their physical activity: sedentary, moderately active, and highly active. Blood was taken before and 30 minutes after exercise in the active groups, and serum creatine kinase and lactate dehydrogenase levels were determined. In addition, heart rate and blood lactate concentrations were measured.
There was no significant difference between the two groups in terms of initial levels of CK and LDH enzymes, i.e., (p > 0.05). However, after exercise, there was a significant increase in levels of CK and LDH enzymes in moderate and high activity groups, i.e., (p < 0.001), with higher levels of enzymes in highly active individuals.
The increase in CK levels is related to muscle stress during exercise and is a result of temporary changes in cell membrane permeability, and the increase in LDH levels relates to increased demand during exercise. This combination of markers gives a picture of what happens in terms of structure and metabolism in the muscles.
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