Riyad. D. S. Synthesis, Characterization, and Biological Activity of Mixed-Ligand Cadmium Cd(II) Complexes with 5-Benzylthio-1H-tetrazole and Phosphines.
Article Sidebar
This work is licensed under a Creative Commons Attribution 4.0 International License.
Main Article Content
Abstract
Abstract:
The research included the preparation and characterization of new cadmium(II) complexes using the ligand 5-(Benzylthio)-1H-tetrazole (L) as a base material, in the presence of mono- and bidentate phosphines. The complexes [CdL2(PPh3)2]Cl2, [Cd2L4(µ-dppm)2]Cl2, and [CdL2(dppp)]Cl2 were obtained. Scanning electron microscopy (SEM), nuclear magnetic resonance spectroscopy (1H-NMR), Fourier-transform infrared spectroscopy (FTIR), and 31P-NMR were created.The spectral results showed that the ligand (L) behaved as bidentate through coordination via nitrogen atoms, while the phosphine ligands coordinated through phosphorus atoms. SEM analysis also revealed that the complexes possess regular nanostructures. The research further included evaluating the biological activity of the prepared compounds against bacteria, fungi, and cancer cells. This study contributes to the development of new metal complexes with distinctive biological activity, opening promising prospects for their use in pharmaceutical and environmental applications.
Downloads
Article Details
References
HUSSEIN, Mohamed, et al. Recent Advances in the Chemistry of Tetrazole Derivatives-A Quinquennial Update (Mid-2019 to date). Mini-Reviews in Organic Chemistry, 2025.
ALSHARGABI, Arwa. Diclofenac derivatives as promising anticancer and anti-inflammatory drug: synthesis, formulations, and pharmacokinetics. Journal of Drug Delivery Science and Technology, 2024, 95: 105544.
https://www.sciencedirect.com/topics/chemistry/tetrazole
TISSEH, Zeinab Noroozi, et al. Catalyst-free, aqueous and highly diastereoselective synthesis of new 5-substituted 1H-tetrazoles via a multi-component domino Knoevenagel condensation/1, 3 dipolar cycloaddition reaction. Tetrahedron, 2012, 68.6: 1769-1773.
BALOUIRI, Mounyr; SADIKI, Moulay; IBNSOUDA, Saad Koraichi. Methods for in vitro evaluating antimicrobial activity: A review. Journal of pharmaceutical analysis, 2016, 6.2: 71-79.
GONELIMALI, Faraja D., et al. Antimicrobial properties and mechanism of action of some plant extracts against food pathogens and spoilage microorganisms. Frontiers in microbiology, 2018, 9: 1639.
MOHAMMED, Azad; ABDULLAH, Avin. Scanning electron microscopy (SEM): A review. In: Proceedings of the 2018 international conference on hydraulics and pneumatics—HERVEX, Băile Govora, Romania. 2018. p. 7-9.
SUN, Cheng, et al. Versatile application of a modern scanning electron microscope for materials characterization. Journal of Materials Science, 2020, 55.28: 13824-13835.
SHAIKH, Saba Kauser J., et al. Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses. European Journal of Medicinal Chemistry, 2017, 128: 258-273.
UPPADHAYAY, Ravish Kumar, et al. STRUCTURAL, PHYSICAL, SURFACE AND NMR STUDY OF 5-(BENZYLTHIO)-1H-TETRAZOLE COMPOUND. Journal of Pharmaceutical Negative Results, 2022, 13.
UPPADHAYAY, Ravish Kumar, et al. STRUCTURAL, PHYSICAL, SURFACE AND NMR STUDY OF 5-(BENZYLTHIO)-1H-TETRAZOLE COMPOUND. Journal of Pharmaceutical Negative Results, 2022, 13.
HAMEED, Anwar A., et al. Exploration of novel phenyl mercury tetrazole‐thione complexes: characterization and investigating the impact of diamine ligands on enhanced hydrogen storage. Energy Storage, 2024, 6.2: e598.