Evaluation the level of Serum cytokines as risk factor for COVID-19 complication in patients with Type-2 diabetes mellitus

Abstract

A cross sectional study was carried out to evaluate the antioxidant state in sera of patients with diabetes mellitus-DM and infected with COVID-19. The study was conducted on 90 blood samples, Group1(G1) include 25 samples for patients with type 2 diabetes mellitus, Group 2(G2) include 40 samples for patients with type 2 diabetes mellitus and infected with COVID-19, Control group, which include 25 samples for healthy individuals, with age range  (40-75) year. Patient samples were collected from Samarra General Hospital(isolation unit), outpatient medical clinics, as well as centers for sonar and spiral units from the period between 20/12/2020 -  20/2/2021. The present study includes the determination of serum fasting glucose-FSG, C-reactive protein-CRP, D-dimerوInterlukin 6-IL-6 ,Tumor necrosis factor-TNF-α, Interferon gamma-INF-γ .

   The results indicate that the level of FSG significantly increased (P≤0.05) in G1 and G2 as compared with the control group, with no significant difference between G1 and G2. While the level of serum CRP significantly increased (P≤0.05) in G1 and G2 , with a significant increased (P≤0.05) in G2 as compared with G1. The level of serum IL-6 and TNF-α ,IFN-γ significantly increase (P≤0.05) in G1 and G2, with a significant increase  (P≤0.05) in G2 as compared with G1. While the INF-γ with no significant difference between G1 and G2. While the level of Plasma D-dimer significantly increased (P≤0.05) in G1 and G2 , with a significant increased (P≤0.05) in G2 as compared with G1.