Evaluation of Interleukin- 5 in Mild and Moderate Asthmatic Patients Following Corticosteroid Therapy

Abstract

Background: Asthma is a heterogeneous complex disease with high prevalence and natural course chronicity. The disease presented as cough variant asthma or shortness of breath which mainly due to inflammation and immunological responses that are induced in respiratory system.
Aim: this study was conducted to determine the role of interleukin 5 as asthmatic biomarker in Iraqi community in order to target the trait.
Patients and Methods: Serum level of interleukin-5 [SIL-5] which is one of the inflammatory markers in asthma was estimated in 90 persons including those with asthma on steroid therapy (35 patients) and those without steroid (35 patients) therapy and the healthy control group (20 persons).
Results: The mean level of SIL-5 was high in moderate asthmatic patients without steroid in their treatment protocol (16.56 pg/ml), while it was less in mild asthmatic patients without steroid therapy. SIL-5 mean values were lower in mild and moderate asthmatic patients who receive steroid therapy (3.94 pg/ml, 4.10 pg/ml respectively). While it was least in the control healthy group (3.32 pg/ml).
Conclusion: Serum IL-5 is predictive biomarkers for asthma severity and treatment response monitoring in Iraqi subjects with asthma