Relevance of IL-4, IL-5 and IL-6 in Women with Toxoplasmosis in Erbil

Abstract

Background: Toxoplasmosis is a common infection in women with child
bearing age and may attribute to bad obstetric outcomes.
Aim: This study was conducted to evaluate IL-4, IL-5 and IL-6 levels in
women with toxoplasmosis and their relevance to this infection.
Materials and Methods: Sixty eight women were included in this study
with a history of abortion (single or repeated). They were referred to by
physicians from different hospitals and private laboratories in Erbil/ Kurdistan
region of Iraq from March 2010 until March 2011 for the detection of antitoxoplasma
antibodies and 30 healthy women were selected as control. Venous
blood samples were collected from these women; serum was obtained for
ELISA test for the detection of anti- toxoplasma IgG and IgM. Levels of IL-4,
IL-5 and IL-6 in these women were also detected.
Results: Fifty one women (75%) who had a single or repeated abortion were
infected with Toxoplasmosis and had positive ELISA tests. From those, eleven
(21.6%) had IgM, twenty five (49%) had IgG and fifteen (29.4%) had both IgM
and IgG. The levels of IL-4, IL-5 and IL-6 were significantly high compared to
the control.
Conclusion: Cellular immune response was highly involved during acute and
chronic Toxoplasmosis