Comparison of the effect of ketamine and propofol on surgical operation patients

Ketamine and propofol combination

Abstract

Background and objective: A prospective randomized controlled study was conducted to compare and evaluate the quality of anesthesia with ketamine or propofol.

Materials and methods:  80 patients, aged 18-50 years, who were scheduled to undergo minor surgeries of short duration (less than 1 hour of expected duration) were selected and divided in two groups.  The patients were randomly assigned to the first group and the second group of 40 patients in each.  Group I patients were given ketamine injection 0.5 mg/kg and group II received propofol injection (1.5 μg/kg) as a co-induction agent.  After 2 minutes, induction of anesthesia was given with propofol (2.5 mg/kg) and an appropriately sized laryngeal mask was inserted.  Anesthesia was maintained with 60% NO in O2 and an intermittent bolus of propofol injection (0.5 mg/kg) given after significant changes in heart rate, blood pressure, lacrimation, sweating, and abnormal movements were noted.

Results: There was a significant decrease (P < 0.05) in pulse rate, systolic and diastolic blood pressure at 1, 3 and 5 minutes in the group receiving propofol, while the change was insignificant (P > 0.05) at 10 minutes.

Conclusion: It was noted that ketamine as a starting material was better than propofol with regard to hemodynamic stability and caused fewer adverse effects during surgery and after surgery.