Evaluation of the level of C1q protein linked with tumor necrosis factor and the oxidative stress state in epilepsy patients using carbamazepine

Authors

Keywords:

C1q TNF-linked protein, carbamazepine, AST, Malondialdehyde, glutathione, peroxynitrite.

Abstract

The current study was conducted on 90 serum samples, divided into two groups: patients, which included 60 samples of males with epilepsy treated by carbamazepine, and 30 serum samples for healthy individuals as a control group. The samples were collected from different areas of Salah al-Din Governorate and Dr. Saad Al-Wetri Hospital for Neurosciences in Baghdad for the period between 2022/11/22 and 2023/1/1. The study included the determination of the concentration of C1q tumor necrosis factor-related protein-9(CTRP9), liver enzymes (alanine aminotransferase-ALT and aspartate aminotransferase-AST), antioxidant parameters (glutathione-GSH, glutathione peroxidase-GPX), and oxidative stress parameters (malondialdehyde-MDA, and peroxynitrite). The results of the current study showed a significant increase in the levels of CTRP9, MDA, peroxynitrite, AST, and GPX in the sera of patients with epilepsy treated with carbamazepine and the control group. The results also showed that there were no significant differences in the activity of the ALT and GSH concentrations in the groups under investigation.

We conclude from the present results that the long use of carbamazepine may cause an increase in the CTRP9 level and induce oxidative stress in patients.

References

- Pellock, JM. Carbamazepine side effects in children and adults. Epilepsia, 1987, 28: S64-S70.‏

- Whalen, Karen. Lippincott Illustrated Reviews: Pharmacology. Wolters Kluwer India Pvt Ltd, 2018.‏

- Apfelbaum JD, Caravati EM, Kerns WP 2nd, Bossart PJ, Larsen G. Cardiovascular effects of carbamazepine toxicity. Ann Emerg Med. 1995 May;25(5):631-5.

- Mahgoub A, Abdoun M, Azam S, Babiker R. Effect of Carbamazepine and Sodium Valproate on Liver Enzymes of Epileptic Children. Dr. Sulaiman Al Habib Medical Journal, 2020;2(3):123-7.

-Star K, Edwards IR, Choonara I. Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase. PLoS One. 2014 Oct 10;9(10):e108970.

- Talaat FM, Kamel T, Rabah AM, Ahmed SM, El-Jaafary SI, Abdelaziz GH. Epilepsy and antiepileptic drugs: risk factors for atherosclerosis. Int J Neurosci. 2015;125(7):507-11.

- Hsieh CY, Lai EC, Yang YH, Lin SJ. Comparative stroke risk of antiepileptic drugs in patients with epilepsy. Epilepsia. 2013 Jan;54(1):172-80.

- Tan TY, Lu CH, Chuang HY, Lin TK, Liou CW, Chang WN, Chuang YC. Long-term antiepileptic drug therapy contributes to the acceleration of atherosclerosis. Epilepsia. 2009 Jun;50(6):1579-86.

-Huang Z, Cui T, Liu J, Zhuang Y, Meng Q, Tao L, Li Z. Characterization of the expression of CTRP9, a paralog of adiponectin. Tsinghua Science & Technology. 2008 Aug 1;13(4):492-9.

- Li J, Zhang P, Li T, Liu Y, Zhu Q, Chen T, Liu T, Huang C, Zhang J, Zhang Y, Guo Y. CTRP9 enhances carotid plaque stability by reducing pro-inflammatory cytokines in macrophages. Biochem Biophys Res Commun. 2015 Mar 20;458(4):890-5.

- Zhang H, Gong X, Ni S, Wang Y, Zhu L, Ji N. C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway. Int Immunopharmacol. 2019 Dec;77:105934. ‏

- Green, MJ, Hill H, Allen O. Chemistry of dioxygen. In: Methods in enzymology. Academic Press, 1984. p. 3-22.‏

- Sedlak J, Lindsay R. H. “Analytical Biochemistry” 1968 p.192 .

- Guidet B, Shah S. The level of malondialdehyde after activation with H2O2 and CuSO4 and inhibition by deferoxamine and molsidomine in the serum of patient with acute Myocardial infarction. National J. Chem, 1989;5(1):139-48.

- Van Uffelen EB, Van der Zee J, de Kister MB, Van Steveninck J, Elferink GJ. Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration. Biochemical Journal. 1998 Mar 1;330(2):719-22.

-Caraco Y, Zylber‐Katz E, Berry EM, Levy M. Significant weight reduction in obese subjects enhances carbamazepine elimination. Clinical Pharmacology & Therapeutics. 1992 May;51(5):501-6.

- Im DU, Kim SC, Chau GC, Um SH. Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-catenin Expression. Cells. 2019 Nov 18;8(11):1460.

- Huang C, Zhang P, Li T, Li J, Liu T, Zuo A, Chen J, Guo Y. Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice. Mol Cell Biochem. 2019 May;455(1-2):99-108.

- Mahgoub A, Abdoun M, Azam S, Babiker R. Effect of Carbamazepine and Sodium Valproate on Liver Enzymes of Epileptic Children. Dr. Sulaiman Al Habib Medical Journal, 2020;2(3):123-127.‏

- Hadzagic-Catibusic F, Hasanbegovic E, Melunovic M, Zubcevic S, Uzicanin S. Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children. Med Arch. 2017 Aug;71(4):239-242.

- Hussein RRS, Pandeya A, Shakya D, Pokharel R. Effect of antiepileptic drugs on liver enzymes. Beni-Suef University Journal of Basic and Applied Sciences, 2013 Mar 1;2(1):14-9.‏

- Ennulat D, Walker D, Clemo F, Magid-Slav M, Ledieu D, Graham M, Botts S, Boone L. Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man. Toxicol Pathol. 2010 Aug;38(5):810-28.

- Egunsola O, Choonara I, Sammons HM, Whitehouse WP. Safety of antiepileptic drugs in children and young people: A prospective cohort study. Seizure. 2018 Mar;56:20-25.

- Aycicek A, Iscan A. The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children. European Neurology, 2007 Dec 15;57(2):65-69.‏

- Solowiej E, Sobaniec W. The effect of antiepileptic drug therapy on antioxidant enzyme activity and serum lipid peroxidation in young patients with epilepsy. Neurologia Neurochirurgia Polska, 2003 Sep 1;37(5):991-1003.‏

- Barrera G, Pizzimenti S, Daga M, Dianzani C, Arcaro A, Cetrangolo GP, Giordano G, Cucci MA, Graf M, Gentile F. Lipid Peroxidation-Derived Aldehydes, 4-Hydroxynonenal and Malondialdehyde in Aging-Related Disorders. Antioxidants (Basel). 2018 Jul 30;7(8):102.

- Nemade ST, Melinkeri R R. Oxidative and antioxidative status in epilepsy. Pravara Med Rev, 2010;2(4):8-10.‏

- Gönenç A, Ozkan Y, Torun M, Simşek B. Plasma malondialdehyde (MDA) levels in breast and lung cancer patients. J Clin Pharm Ther. 2001 Apr;26(2):141-4.

- Mannaerts D, Faes E, Cos P, Briedé JJ, Gyselaers W, Cornette J, Gorbanev Y, Bogaerts A, Spaanderman M, Van Craenenbroeck E, Jacquemyn Y. Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function. PLoS One. 2018 Sep 11;13(9):e0202919.

- Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian Journal Clinical Biochemistry, 2015 Jan;30:11-26.

- Gopal N, Selvam A, Muddegouda PH. Serum Gamma GlutamylTransferase levels in Obese South Indian adults with reference to atherogenic lipid risk factors and lipid peroxides. Int J Med Health Sci, 2012;1(2):35-42.

- Karabiber H, Yakinci C, Durmaz Y, Temel I, Mehmet N. Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine. Brain Dev. 2004 Jan;26(1):15-8.

- Peker E, Oktar S, Ari M, Kozan R, Doğan M, Cağan E, Söğüt S. Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid. Brain Res. 2009 Nov 10;1297:194-7. ‏

-الحسني، أويس موفق حامد. تأثير الإصابة بعدد من الأورام السرطانية في بيروكسدة الدهن ومستوى الكلوثاثيون وعدد من المتغيرات في مكونات الدم. رسالة ماجستير، كلية العلوم جامعة الموصل 2004.

- Ling C, Cui M, Chen J, Xia L, Deng D, Gu Y, Wang P. A novel highly selective fluorescent probe with new chalcone fluorophore for monitoring and imaging endogenous peroxynitrite in living cells and drug-damaged liver tissue. Talanta. 2020 Aug 1;215:120934.

- Beltrán-Sarmiento E, Arregoitia-Sarabia CK, Floriano-Sánchez E, Sandoval-Pacheco R, Galván-Hernández DE, Coballase-Urrutia E, Carmona-Aparicio L, Ramos-Reyna E, Rodríguez-Silverio J, Cárdenas-Rodríguez N. Effects of Valproate Monotherapy on the Oxidant-Antioxidant Status in Mexican Epileptic Children: A Longitudinal Study. Oxid Med Cell Longev. 2018 Dec 4;2018:7954371.

- Arioz DT, Camuzcuoglu H, Toy H, Kurt S, Celik H, Aksoy N. Serum prolidase activity and oxidative status in patients with stage I endometrial cancer. Int J Gynecol Cancer. 2009 Oct;19(7):1244-7.

- Yüksel A, Cengiz M, Seven M, Ulutin T. Erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children with valproate and carbamazepine monotherapy. J Basic Clin Physiol Pharmacol. 2000;11(1):73-81.

- Wang M, Zhang X, Jia W, Zhang C, Boczek T, Harding M, Liu Y, Li M, Zhang S, Lei S, Zhang D, Guo F. Circulating glutathione peroxidase and superoxide dismutase levels in patients with epilepsy: A meta-analysis. Seizure. 2021 Oct;91:278-286. ‏

- Saeed M, Imran M, Baig MH, Kausar MA, Shahid S, Ahmad I. Virtual screening of natural anti-filarial compounds against glutathione-S-transferase of Brugia malayi and Wuchereria bancrofti. Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):69-73.

- Ahmad P, Jamsheed S, Hameed A, Rasool S. Drought stress induced oxidative damage and antioxidants in plants. In: Oxidative damage to plants. Academic Press, 2014. p. 345-367.

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Published

2024-05-01

How to Cite

Al-Samarrai, H. M. A. ., Al-Samarrai, R. R. H. ., Alsammarraie, H. J. ., & Jameel, M. T. . (2024). Evaluation of the level of C1q protein linked with tumor necrosis factor and the oxidative stress state in epilepsy patients using carbamazepine. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 7(2), 23–41. Retrieved from https://isnra.net/index.php/ijms/article/view/1170