Evaluation of the level of C1q protein linked with tumor necrosis factor and the oxidative stress state in epilepsy patients using carbamazepine
Keywords:
C1q TNF-linked protein, carbamazepine, AST, Malondialdehyde, glutathione, peroxynitrite.Abstract
The current study was conducted on 90 serum samples, divided into two groups: patients, which included 60 samples of males with epilepsy treated by carbamazepine, and 30 serum samples for healthy individuals as a control group. The samples were collected from different areas of Salah al-Din Governorate and Dr. Saad Al-Wetri Hospital for Neurosciences in Baghdad for the period between 2022/11/22 and 2023/1/1. The study included the determination of the concentration of C1q tumor necrosis factor-related protein-9(CTRP9), liver enzymes (alanine aminotransferase-ALT and aspartate aminotransferase-AST), antioxidant parameters (glutathione-GSH, glutathione peroxidase-GPX), and oxidative stress parameters (malondialdehyde-MDA, and peroxynitrite). The results of the current study showed a significant increase in the levels of CTRP9, MDA, peroxynitrite, AST, and GPX in the sera of patients with epilepsy treated with carbamazepine and the control group. The results also showed that there were no significant differences in the activity of the ALT and GSH concentrations in the groups under investigation.
We conclude from the present results that the long use of carbamazepine may cause an increase in the CTRP9 level and induce oxidative stress in patients.
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