A Study of Cellular Toxicity of some Nano Cationic Polymers in BT, MCF7 and SKBR3 Breast Cancer Cell Lines

Maysoon  Zaboon; Hadi S.  Al-Lami; Afrodet A Saleh

Authors

Maysoon Zaboon Department of Chemistry, University of Basrah College of Science [BUCOS] https://orcid.org/0000-0001-6853-5341
Hadi S. Al-Lami Department of Chemistry, University of Basrah College of Science [BUCOS], https://orcid.org/0000-0001-8716-6385
Afrodet A Saleh Department of Pathological Analyses, University of Basrah College of Science [BUCOS] https://orcid.org/0000-0003-4398-855X

Keywords:

MTT, cellular toxicity, cationic polymers, SEM, cell viability, nanoparticles

Abstract

Aim: This study conducted aiming to develop antitumor system.
Materials and methods: In this work, some cationic polymers which are namely; poly ethylene glycol (PEG), poly vinyl alcohol (PVA), poly vinyl pyrrolidone (PVP), and polylactide (PLA) were converted to nanoparticles in size by subjecting them to the sonication method. They were evaluated as anticancer potency towards human breast carcinoma cells. The cancer cells were monitored under a fluorescence microscope after treatment with propidium iodide.
Results: MTT assay revealed the higher cytotoxic efficacy of cationic polymers NPs than non-treated cell lines. In addition, results also suggest that PLA NPs exposure the cell viability decreased highly significant than other types of NPs polymers. Conclusion: PLA NPs demonstrated strong antitumor activity in vitro by reducing cell viability

A Study of Cellular Toxicity of some Nano Cationic Polymers in BT, MCF7 and SKBR3 Breast Cancer Cell Lines

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