Immunological and Molecular Study of IL-33 and ST2 Receptor in a Sample of Iraqi Patients with Breast Cancer

Breast cancer

Abstract

Breast cancer is the main cause of cancer-related deaths in developing countries and the most frequently diagnosed cancer among women worldwide. In Iraq, Breast cancer considered the most common cancer compared to other types of cancer.
Aim: The study aimed to investigate the serological and polymorphism of Interleukin-33 (IL-33) and its receptor growth Stimulation (ST2), as well as to evaluate the serum level of Nitric Oxide (NO) and its relationship with the development of breast cancer in Iraqi women.Breast cancer is the main cause of cancer-related deaths in developing countries and the most frequently diagnosed cancer among women worldwide. In Iraq, Breast cancer considered the most common cancer compared to other types of cancer.
Aim: The study aimed to investigate the serological and polymorphism of Interleukin-33 (IL-33) and its receptor growth Stimulation (ST2), as well as to evaluate the serum level of Nitric Oxide (NO) and its relationship with the development of breast cancer in Iraqi women.Breast cancer is the main cause of cancer-related deaths in developing countries and the most frequently diagnosed cancer among women worldwide. In Iraq, Breast cancer considered the most common cancer compared to other types of cancer.
The study aimed to investigate the serological and polymorphism of Interleukin-33 (IL-33) and its receptor growth Stimulation (ST2), as well as to evaluate the serum level of Nitric Oxide (NO) and its relationship with the development of breast cancer in Iraqi women.Breast cancer is the main cause of cancer-related deaths in developing countries and the most frequently diagnosed cancer among women worldwide. In Iraq, Breast cancer considered the most common cancer compared to other types of cancer.
Aim: The study aimed to investigate the serological and polymorphism of Interleukin-33 (IL-33) and its receptor growth Stimulation (ST2), as well as to evaluate the serum level of Nitric Oxide (NO) and its relationship with the development of breast cancer in Iraqi women. There was decreased IL-33 serum level after surgery performance in patients with breast cancer. Elevation of serum concentration of sST2 may be suggested as a biomarker for the monitoring of breast cancer prognosis. There was no association between breast cancer development and IL-33 SNP (rs1929992) was detected in the present study cohort. The heterozygous genotype AG was the common genotype in the Iraqi women. The allele G was associated with breast cancer and may play a role of risk factor, however, the allele A may be a preventive factor for the development of breast cancer. Allele A associated with the increase in serum IL-33 in women with AA and AG genotypes in control group. In contrast, GG genotype was associated with the increase in IL-33 serum level in women with breast cancer. Genotype GG and allele G were more frequent in women with breast cancer and thus may act as risk factor. There are some polymorphisms noticed in the distal promoter of ST2 gene, SNP (-27128C/T) and showed a significant differences between patients and control, and T allele may has a preventive role for breast cancer development in Iraqi women.