Inflammation in Asthma Pathogenesis: Role of Eosinophil, Basophils, Neutrophil and Mast Cells

Asthma pathogenesis

Abstract

Asthma is a common chronic airway disease worldwide. Recent studies findings suggested that asthma is not a single disease entity, but it is a syndrome that characterised shortness of breath, intermittent attack, cough and wheezing. The disease onset commonly occurred during childhood. The natural history of asthma is variable and the disease not restricted to children, also it affects adults and both gender. Asthma pathogenesis is a complex scenario interplay of sequences of inflammation, immune responses, and airway remodelling. Thus the disease presented with different phenotypes and endotypes which are with variable treatment outcomes. The chronic inflammation is a main corner stone of asthma pathogenesis during attack and during asymptomatic course. The inflammation and immune responses are induced by the inhaled allergens and multiple host cells are involved in asthma pathogenesis. In this review we present the role of eosinophils, basophils and neutrophils in pathogenesis of asthma.