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Huda Mawlood Taher huda.mawlood@uokirkuk.edu.iq
Hiyam Jamal Ibrahim plantanatomy@uokirkuk.edu.iq
Bayan Mohammed Mahdi bayanmohammad@uokirkuk.edu.iq


Abstract

 Monkeypox is a disease caused by the monkeypox virus, which is related to the smallpox virus. It is a double-strand DNA virus enclosed in an envelope and a member of the Orthopoxvirus genus within the Orthopoxviridae family. This disease was spread in West and Central African countries and other regions as well. It transmits through direct contact with the skin lesions of an infected person, as well as through respiratory droplets and contaminated materials. Monkeypox is generally less severe than smallpox, and most people recover completely from it; however, it is still serious, especially for young children, pregnant women, and people with weakened immune systems. It causes pain, fever, rash, and swollen lymph nodes.

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How to Cite
Taher, H. M., Ibrahim, H. J., & Mahdi, B. M. (2025). Monkeypox Virus: A Review. Al-Kitab Journal for Pure Sciences, 9(02), 128–139. https://doi.org/10.32441/kjps.09.02.p8
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Review Article

References

Centers for Disease Control and Prevention. Monkeypox-2024 Available from: https://www.cdc.gov/ poxvirus/monkeypox/index.html

Durski KN, McCollum AM, Nakazawa Y, et al. Emergence of monkeypox in West Africa and Central Africa, 1970–2017. Wkly Epidemiol Rec. 2018;93(11):125–132.

Monkeypox virus infection in the united states and other non- endemic countries—2022. https://emergency.cdc.gov/han/2022/ han00466.asp.

Guarner J, Del Rio C, Malani PN. Monkeypox in 2022—what clinicians need to know [published online ahead of print. JAMA. 2022. https://doi.org/10.1001/jama.2022.10802

Von Magnus P, Andersen EK, Petersen KB, Birch Andersen A. A pox-like disease in cynomolgus monkeys.Acta Pathol Microbiol Scand 1959; 46: 156–76.

Breman JG, Kalisa R, Steniowski MV, Zanotto E, Gromyko AI, Arita I. Human monkeypox, 1970–79. Bull World Health Organ. 1980; 58(2):165–182.

Monkeypox Outbreak Global Map | monkeypox | Poxvirus | CDC 2023. https://www.cdc.gov/poxvirus/mpox/ 2023 June.

Sabeena S. The changing epidemiology of monkeypox and preventive measures: an update. Arch Virol 2023; 168:31.

Jezek Z, Grab B, Szczeniowski M, Paluku KM, Mutombo M. Clinico-epidemiological features of mon- keypox patients with an animal or human source of infection. Bull World Health Organ. 1988; 66 (4):459–464.

Vora S, Damon I and Fulginiti V. Severe eczema vaccinatum in a household contact of a smallpox vaccinee. Clin Infect Dis. 2008.

Burnett JC, Henchal EA, Schmaljohn AL, Bavari S. The evolving field of biodefence: therapeutic developments and diagnostics. Nat Rev Drug Discov. 2005; 4:281–97.

Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B, et al. Extended human-to-human transmission during a monkeypox outbreak in the Democratic Republic of the Congo. Emerg Infect Dis. 2016; 22(6):1014–1021.

Olson VA, Laue T, Laker MT, et al. Real-time PCR system for detection of orthopoxviruses and simultaneous identification of smallpox virus. J Clin Microbiol 2004; 42:1940–6.

Chittick G, Morrison M, Brundage T, Nichols WG. Short-term clinical safety profile of brincidofovir: a favorable benefit–risk proposition in the treatment of smallpox. Antiviral Res. 2017. https://doi.org/10.1016/j.antiviral.2017.01.009

Bunge EM, Hoet B, Chen L, et al. The changing epidemiology of human mon- keypox-a potential threat? A systematic review. PLoS Negl Trop Dis 2022;16(2): e0010141.

Beer EM, Rao VB. A systematic review of the epidemiology of human monkey- pox outbreaks and implications for out- break strategy. PLoS Negl Trop Dis 2019; 13(10):e0007791.

Yinka-Ogunleye A, Aruna O, Dalhat M, et al. Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis 2019; 19:872-9

Doshi RH, Alfonso VH, Morier D, et al. Monkeypox rash severity and animal ex- posures in the Democratic Republic of the Congo. Ecohealth 2020;17:64-73.

Besombes C, Gonofio E, Konamna X, et al. Intrafamily transmission of mon- keypox virus, Central African Republic, 2018. Emerg Infect Dis 2019;25:1602-4.

Vandenbogaert M, Kwasiborski A, Gonofio E, et al. Nanopore sequencing of a monkeypox virus strain isolated from a pustular lesion in the Central African Re- public. Sci Rep 2022;12:10768.

Nolen LD, Osadebe L and Katomba J. Extended human-to-human transmission during a monkeypox outbreak in the Democratic Republic of the Congo. Emerge Infect Dis 2016;22:1014-21.

Ogoina, D.; Iroezindu, M.; James, H.I.; Oladokun, R.; Yinka-Ogunleye, A.; Wakama, P.; Otike-Odibi, B.; Usman, L.M.; Obazee, E and Aruna, O.Clinical Course and Outcome of Human Monkeypox in Nigeria. Clin. Infect. Dis. 2020, 71, e210–e214.

Jezek, Z.; Szczeniowski, M.; Paluku, K.M.; Mutombo, M. Human Monkeypox: Clinical Features of 282 Patients. J. Infect. Dis. 1987;156: 293–298.

WHO. Monkeypox. Available online: https://www.who.int/news-room/fact-sheets/detail/monkeypox. 2022 July.

Adler, H.; Gould, S.; Hine, P.; Snell, L.B.; Wong, W.; Houlihan, C.F.; Osborne, J.C.; Rampling, T.; Beadsworth, M.B and Duncan, C.J. Clinical features and management of human monkeypox: A retrospective observational study in the UK. Lancet Infect. Dis. 2022.

Osadebe, L.; Hughes, C.M.; Lushima, R.S.; Kabamba, J.; Nguete, B.; Malekani, J.; Pukuta, E.; Karhemere, S.; Tamfum, J.-J.M.; Okitolonda, E.W.; et al. Enhancing case definitions for surveillance of human monkeypox in the Democratic Republic of Congo. PLOS Negl. Trop. Dis. 2017, 11, e0005857

Huhn, G.D.; Bauer, A.M.; Yorita, K.; Graham, M.B.; Sejvar, J.; Likos, A.; Damon, I.K.; Reynolds, M.; Kuehnert, M.J. Clinical Characteristics of Human Monkeypox, and Risk Factors for Severe Disease. Clin. Infect. Dis. 2005; 41: 1742–1751

Mbala, P.K.; Huggins, J.W.; Riu-Rovira, T.; Ahuka, S.M.; Mulembakani, P.; Rimoin, A.W.; Martin, J.W.; Muyembe, J.-J.T. Maternal and Fetal Outcomes Among Pregnant Women with Human Monkeypox Infection in the Democratic Republic of Congo. J. Infect. Dis. 2017;216: 824–828

Damon, I.K. Status of human monkeypox: Clinical disease, epidemiology and research. Vaccine 2011; 29: D54–D59.

Hussein, F. K., Mahmoud, A. J., and Yousif, B. J. Estimation of Immunoglobulin A, Immunoglobulin G, and Immunoglobulin M Antibody Levels in Laboratory Mice Balb/c Infected with Entamoeba histolytica and Treatment with Aqueous Extracts of Cyperus rotundus and Thymus serpyllum. Polytechnic Journal.2020; 10(1), 21.

Yi X.M, Lei Y.L, Li M, Li Z, Li S. The monkeypox virus-host interplays. Cell Insight. 2024:100185

Estep RD, Messaoudi I, O'Connor MA, Li H, Sprague J, Barron A, et al. Deletion of the monkeypox virus inhibitor of complement enzymes locus impacts the adaptive immune response to monkeypox virus in a nonhuman primate model of infection. Journal of virology. 2011;85(18):9527-42.

Shchelkunov SN. An increasing danger of zoonotic orthopoxvirus infections. PLoS pathogens. 2013;9(12):e1003756.

Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. The Lancet Infectious Diseases. 2022;22(8):1153-62

Kulesh DA, Loveless BM, Norwood D, et al. Monkeypox virus detection in rodents using real-time 3f-minor groove binder TaqMan assays on the Roche Light Cycler. Lab Invest 2004; 84:1200–8.

Bayer-Garner IB. Monkeypox virus: histologic, immunohistochemical and electron-microscopic findings. J Cutan Pathol 2005; 32:28–34.

Gentile M, Gelderblom HR. Rapid viral diagnosis: role of electron microscopy. New Microbiol 2005; 28:1–12.

Damon IK, Esposito JJ. Poxviruses that infect humans. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolker MH, eds. Manual of clinical microbiology. 8th ed. Washington, DC: ASM Press, 2003:1583–91

Taher, H. M. Levels Estimation of Iron, Zinc and Copper in the Serum of Children Infected with Giardiasis. Al-Kitab Journal for Pure Sciences.2024; 8(02), 120-124.

Lapa S, Mikheev M, Shchelkunov S, et al. Species-level identification of orthopoxviruses with an oligonucleotide microchip. J Clin Microbiol 2002; 40:753–7.

Guarner J, Del Rio C, Malani PN. Monkeypox in 2022-what clinicians need to know. JAMA. 2022;328(2):139–40.

Centers for Disease Control and Prevention. Impact of monkeypox outbreak on select behaviors. 2022. https://www.cdc.gov/poxvirus/monkeypox/response/2022/amis-select behaviors.html#:~:text=In%20an%20online%20survey%20of,encounters%2C%20and%2050%25%20reported%20reducing. Accessed 19 Oct 2022.

Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci USA. 2010;107(37):16262–7.

Centers for Disease Control and Prevention. Monkeypox and smallpox vaccine guidance. 2022. https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html. Accessed 26 Sept 2022.

Amer, F., Khalil, H. E., Elahmady, M., ElBadawy, N. E., Zahran, W. A., Abdelnasser, M.and Tash, R. M. E. Monkeypox: Risks and approaches to prevention. Journal of infection and public health.2023; 16(6), 901-910.

Guarner J, Del Rio C, Malani PN. Monkeypox in 2022-what clinicians need to know. JAMA. 2022;328(2):139–40.

Reynolds MG, McCollum AM, Nguete B, Lushima RS, Petersen BW. Improving the care and treatment of monkeypox patients in low-resource settings: applying evidence from contemporary bio- medical and smallpox biodefense research. Viruses. 2017. https:// doi.org/10.3390/v9120380.

Adler H, Gould S, Hine P, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 2022;S1473–3099(22)00228-6. https://doi. org/10.1016/S1473-3099(22)00228-6.

TPOXX (tecovirimat) [Package Insert]. Corvallis, OR: SIGA Technologies, Inc. 2018. https://www.accessdata.fda.gov/drugs atfda_docs/label/2018/208627s000lbl.pdf. Accessed 2022 May.

Russo AT, Grosenbach DW and Chinsangaram J. An overview of tecovirimat for smallpox treatment and expanded anti-ortho- poxvirus applications. Expert Rev Anti Infect Ther. 2021. https:// doi.org/10.1080/14787210.2020.1819791.

Grosenbach DW, Honeychurch K, Rose EA, et al. Oral tecovirimat for the treatment of smallpox. N Engl J Med. 2018. https://doi.org/ 10.1056/nejmoa1705688.

Quenelle DC, Buller RML, Parker S, et al. Efficacy of delayed treatment with ST-246 given orally against systemic orthopox- virus infections in mice. Antimicrob Agents Chemother. 2007. https://doi.org/10.1128/AAC.00879-06.

Marcinak J, Vora S, Weber S, et al. Household transmission of vaccinia virus from contact with a military smallpox vaccine Illinois and Indiana. Morb Mortal Wkly Rep. 2007.

Taher, H. M. The effect of aqueous and alcoholic extract of Opuntia ficus indica on biochemical parameters and kidney function in rats infected with Echinococcosis. GSC Biological and Pharmaceutical Sciences.2023; 25(2), 244-248.

Hahne S, Macey J, Binnendijk RV, et al. Progressive vaccinia in a military smallpox vaccine—United States. Pediatr Infect Dis J. 2009. https://doi.org/10.1097/inf.0b013e3181b18ed0

US Food and Drug Administration: FDA approves drug to treat smallpox. https://www.fda.gov/drugs/drug-safety-and-availabili ty/fda-approves-drug-treat-smallpox. Accessed 2022 May.

Bakr, M.M., Taher, H. M. & Mohamed, A. H. The Effect of Entamoeba Histolytica Infection on Levels of Adiponectin and Histamine in Children. Bahrain Medical Bulletin.2022; 44(2).

Lanier R, Trost L, Tippin T, et al. Development of CMX001 for the treatment of poxvirus infections. Viruses. 2010. https://doi. org/10.3390/v2122740.

Rice AD, Adams MM, Wallace G, et al. Efficacy of CMX001 as a post exposure antiviral in New Zealand white rabbits infected with rabbit pox virus, a model for orthopoxvirus infections of humans. Viruses. 2011. https://doi.org/10.3390/v3010047.