Blood Groups, IL-6, IL-8 and HS-CRP Levels in Non-Pregnant Women With Urinary Tract Infection Caused by Escherichia coli

Abstract

Background: A urinary tract infection (UTI) is an infectious disease infects the urinary tract which the bladder, urethra, two ureter, and two kidneys and women are more prone to developing UTI.

Objectives: This study was aimed to evaluate the relationship between ABO blood groups and UTI, and investigates serum and urine concentration of IL-6, IL-8 and serum HS-CRP in non-pregnant women patients with UTI (E. coli).

Method: This study was conducted on 400 urine samples collected from patients admitting to Azadi teaching hospital and General Kirkuk hospital labs  in Kirkuk city from December 2015 to May 2016. The frequency distribution of ABO in various phenotypes was assessed. Serum level of HS-CRP, serum and urine levels of Il-6, Il-8 were assessed in 36 UTI patients caused by E. coli, as well as 15 apparently healthy women.

Results: The most common bacteria  causing UTI was Escherichia coli (78.23%), with the highest frequencies observed in two blood groups of A (53.6%) and O(33%). Serum concentration of HS-CRP, serum and urine concentrations of IL-6 and IL-8 were increased significantly (p<0.00) in women infected with UTI caused by E coli compared to controls. A positive correlation between the serum IL-6 and HS-CRP was found(r=0.86).  

Conclusion: The based on our results showed that the serum and urine IL-6, IL-8 contributes in immune response and inflammation of UTI caused by E coli, and the blood group A and O had a higher prevalence rate.