Synthesis, Characterization and Evaluation of Biological Activity of Complexes of Zinc (II), Cadmium (II), Mercury (II) Containing Benzimidazole Derivatives Prepared From the Reaction of 4-methyl-O-phenyldiamine with Glutaric Acid

Abstract

The biological activity of zinc (II), cadmium (II) and mercury (II) complexes was synthesized, diagnosed and studied, containing the prepared ligands. The first ligand L1 was prepared from the reaction of 1 mmol of 4-methyl-O-phenyldiamine with 1 mmol of glutaric acid. As well as preparing complexes of formula [M(L1)2] with binary metal ions zinc, cadmium, mercury in a ratio of (1:2). The geometric shapes of the prepared ligands and complexes were reached by careful analysis of the elements, the infrared spectrum, the ultraviolet-visible spectrum, the proton nuclear magnetic resonance spectrum, and the mass spectrum. The results showed that all the prepared complexes gave a tetrahedral geometric shape. The bacterial activity of the ligands and complexes prepared using two types of bacteria, E.coli and Bacillus subtilis, was studied, and most of them proved the ability of most of them to inhibit the selected bacteria